Endocrine Abstracts

The aim of this study was to compare the long-term co-morbidities and biochemical data between patients with adrenal incidentaloma and ‘autonomous cortisol secretion’ who were treated surgically and conservatively.Methods: The research of the database of the patients with adrenal incidentaloma diagnosed between 2007 and 2014 was performed. Among them, 43 patients with ‘autonomous cortisol secretion’ were identified and invited for a f...

Craniopharyngeoma patients have reduced quality of life and increased cardiovascular mortality because of severe obesity present in about 50% of patients. In the present study we analysed postoperative body mass index (BMI) in craniopharyngeoma patients depending on the presence of the diabetes insipidus (DI).We retrospectively analyzed 19 craniopharyngeoma patients (male:female=12:7, age 31.2 years, range 9–67) treated at our Department since 2001....

Accurate assessment of the hypothalamic–pituitary–adrenal (HPA) axis is important for the appropriate management of patients with pituitary tumours after transsphenoidal surgery. The aim of our study was to evaluate the clinical relevance of the early postoperative basal cortisol level in assessing postoperative HPA axis function. We performed a retrospective analysis of 68 patients (male:female=36:32, age 59.5 years, range 21–77) treated by transsphenoidal surg...

Craniopharyngiomas are rare and histologically benign tumors that are associated with an unfavourable prognosis and controversial optimal treatment. The aim of this retrospective study was to review clinical presentation, natural history and therapeutic outcomes of patients with craniopharyngiomas treated in a single center between 1995 and 2017. In that period, 38 patients (16 children and 22 adults) were diagnosed with craniopharyngioma. Median age at the time of diagnosis i...

Objective: Patients with Cushing syndrome (CS) have impaired health-related quality of life (HRQoL) before and after surgery. The data on the optimal hydrocortisone dose after surgical cure of CS is scarce. Therefore, we investigated the influence of hydrocortisone dose on HRQoL after surgical treatment of CS. We hypothesized that patients who receive higher hydrocortisone doses after surgery would have better HRQoL and fewer cortisol withdrawal symptoms.<p class="abstext"...

Aim: Dopamine agonist (DA) therapy is recommended as first-line treatment for prolactinomas, albeit with long treatment duration and high recurrence rate after treatment withdrawal. The aim of this retrospective study was to evaluate predictors for successful DA withdrawal.Methods: The study included 59 prolactinoma patients (39 female, 20 male; age 34 (18–82) years) that were treated with DA (35.6% on cabergoline); the duration of treatment was 71 ...

The role of systemic inflammation in promoting tumor progression has been a topic of increasing interest. Neutrophil-lymphocyte ratio (NLR) >5 and platelet-lymphocyte ratio (PLR) >190 used as indicators of inflammation have been reported to have prognostic value in numerous solid tumors. The aim of this retrospective study was to investigate NLR and PLR as biomarkers in distinguishing between adrenocortical adenomas and adrenocortical carcinomas (ACC). Nineteen patient...

Introduction: Cushing’s disease (CD) is an uncommon condition of excess endogenous glucocorticoids caused by ACTH secreting pituitary corticotroph adenoma. The purpose of this study is to review therapeutic outcomes and comorbidity of patients with CD in a single centre.Methods: We conducted a retrospective study of 33 patients with CD undergoing transsphenoidal surgery from January 2007 to February 2014. (27 female and six male, median age 38 years...

Empty sella is characterized by the radiological appearance of an enlarged or deformed sella turcica which is completely or partially filled with cerebrospinal fluid resulting in a displacement of the normal pituitary gland. Primary empty sella (PES) refers to the empty sella appearance of unknown etiology, diagnosed after excluding a history of previous pituitary pathology. The prevalence of hypopituitarism in empty sella syndrome varies between 2 and 32% in different publish...

Recognizing the site of origin of craniopharyngioma (CP) along the hypothalamus-pituitary axis according to pre-operative MR is helpful to understand its growth pattern in relation to hypothalamus, which is critical in the prediction of hypothalamic injury and planning of treatment. We retrospectively classified 29 CP according to MR pre-operative image study using modified classification of Tang et al. (Nature, 8:10215, 2018). According to its relation to pituitary s...